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European Heart Journal 1988 9(1):73-86;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Determination of left ventricular wall thickness and muscle mass by intravenous digital subtractionangiocardiography: validation of the method

D. GROB, O. M. HESS, E. MONRAD, B. BIRCHLER, J. GRIMM and H. P. KRAYENBUEHL

Department of Medicine, Medical Policlinic, Cardiology, University Hospital Zurich, Switzerland

Received 27 January 1987; revised 22 May 1987; .

address for correspondence: Otto M. Hess, M. D. Medical Policlinic, Cardiology, University Hospital, Raemistrasse 100, Ch- 8091 Zurch, Switzerland.

Abstract

Left ventricular (LV) wall thickness and muscle mass are important measures of LV hypertrophy. In 24 patients LV end-diastolic wall thickness and muscle mass were determined (two observers) by digital subtraction angiocardiography (DSA) and conventional LV angiocardiography (LVA). Wall thickness was determined over the anterolateral wall of the left ventricle according to the technique of Rackley (method 1) or by planimetry (method 2). Seventeen patients were studied at rest and seven during dynamic exercise. Wall thickness correlated well between LVA and DSA; the best correlations were obtained by a combined subtraction mode using either method 1 or 2 (method 1, r≥0–80; method2, r≥0. 75). The standard error of estimate of the mean (SEE) was slightly lower for method 2 (≤ 10%) than for method 1 (≤ 13%). DSA significantly overestimated wall thickness by 5–7% with method 1 and underestimated by 12–14% with method 2. Muscle mass correlated well between LVA and DSA; the SEE was ≤ 15% for method 1 and≤ 12% for method 2. Overestimation of muscle mass by DSA was 7–11% with method 1 and underestimation was 13–15% with method 2.It is concluded that LV wall thickness can be determined accurately by DSA with an SEE ranging between 10 and 13%. Determination of LV muscle mass is slightly less accurate and the SEE is slightly larger ranging between 13 to 17%. With method 1, wall thickness and muscle mass were over estimated and with method 2 underestimated.

Key Words: Digital subraction angigraphy • left ventricualr wall thickness • left ventricular musle mass • conventionalangicardiography • supine bicycle exercise


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