Skip Navigation

European Heart Journal 1988 9(10):1131-1136;
Copyright © 1988 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by LUCCIONI, R.
Right arrow Articles by PERRET, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LUCCIONI, R.
Right arrow Articles by PERRET, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1988 The European Society of Cardiology

Evaluation of the dose-effect relationship of a new ace inhibitor (perindopril) by an automatic blood pressure recorder

R. LUCCIONI*,, Y. FRANCES*, R. GASS*, C. SCHWAB{dagger}, J. P. SANTONI{dagger} and L. PERRET{dagger}

*Service de Médecine Interne et des Urgences C.H.U. Nord 13326 Marseille Cedex 14
{dagger}I.R.I.S., 22, rue Garnier, 92000 Neuilly sur Seine France

Received 16 December 1987; revised 29 April 1988; .

Address for correspondence: Pr. R. Luccioni, Service de Médecine Interne et des Urgences. C.H U Nord, 13326 Marseille Cedex 15, France.

Abstract

Repeated blood pressure recordings by non-invasive devices are of better predictive value than single measurements in the evaluation of antihypertensive treatment. Such a method has been used to establish the dose-effect relationship of perindopril. After a two-week placebo run-in period, 40 patients with essential hypertension (age 56.6 ± 1.5 years, 31 males, nine females) were treated with placebo or 2, 4 or 8 mg of perindopril once daily for one month following a randomized double-blind design. They were included if at least 75% of diastolic blood pressure recordings, made over an 8 h diurnal period using an automatic blood pressure recorder, were > 95 mmHg on placebo.

Values (mean ± SEM) before and after treatment were assessed using analysis of variance. These data showed a significantly greater reduction of blood pressure with 4 mg and 8 mg daily doses compared to placebo and the 2 mg daily dose. Such results were not obtained with blood pressure levels recorded by a mercury sphygmomanometer, confirming the value of an automatic blood pressure recorder as a tool in therapeutic trials.

Key Words: Hypertension • angiotensin converting enzyme inhibitors • blood pressure automatic measurements


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.