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European Heart Journal 1988 9(11):1200-1205;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardioloy

Labealol in the treatment of stable exertional angina pectoris: a comparison with nifedipine

T. CRAKE, D. MULCAHY, C. WRIGHT and K. FOX

National Heart Hospital Westmoreland Street, London WI,U.K.

Received 26 October 1987; revised 6 June 1988; .

Requests for reprints:Dr Tom Crake, Senior Registrarin Cardiology,St Mary's Hospital, Praed St., London W2 INY, U.K.

Abstract

Labetalol, a combined alpha-and beta-receptor antagonist, was compared with nifedipine in a placebocontrolled, randomized doubled-blind cross over study (four week treatment periods ) of 11 normotensive patients with stable exertional angina pectoris. Standard recomended doses of both drugs (labetalol 200–400 mg twice daily, nifedipine 10–20 mg three times daily) were used. Angina frequency was similar during the placebo washout period and treatment with the two drugs. The duration of treadmill exercise to angina, ischaemia (>1 mm ST segment depression), and end of exercise was increased by both labealol and nifedipine when compared with placebo, but there was no difference between the drugs. Ambulatory ST segment monitoring demonstrated that the frequency, duration and magnitude of ST segment depression, whether painful or silent, were unaffected by either drug.

Labetalol is an effective agent in improving exercise tolerance in normotensive patients with stable exertional angina pectoris, with an efficacy similar to that of nifedipine.

Key Words: Labetalol, • nifedipine, • angina pectoris, • ST segment monitoring.


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