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European Heart Journal 1988 9(11):1223-1229;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Serial pulmonary blood volume changes with supine exercise in normal subjects and in coronary artery disease patients

D. ALEXOPOULOS, S.F. HOROWITZ, J.A. AMBROSE and J. MACHAC

Division of Cardiology, Department of Medicine, The Mount Sinai Medical Centre, One Gustave L.Levy Place New york,NY 10029,U.S.A.

Received 11 March 1988; revised 26 May 1988; .

D.Alexopoulus, M.D.Box 1030, Mount Sinai Medical Centre, 1 Gustave L. Levy Place, New york,NY 10029,U.S.A.

Abstract

Relative changes in pulmonary blood volume (PBV) were assessed serially at first stage, peak and post-supine exercise in 13 young normal volunteers and 33 coronary artery disease (CAD)patients.Gated blood pool imaging was used with time correced count calculation of a region over the lung and comparison to he rest image. In normal subjects, the PBV ratio did not change with exercise but dropped significally immediately post-exercise. In CAD patients, the PBV ratio increased in the first exercise stage, increased further at peak exercise, and fell significantly following exercise cessation. In the three stages studied, significantly higher PBV ratios were demonstrated in the CAD patients compared to normal subjects, but with significant overlap between he two groups. No significant relation was found between PBV changes and the number of diseased vessels, severity score (Gensini), left ventricular end-diastolic pressure, exercise-limiting symptoms,and left and right ventricular ejection fraction at rest and with exercise. Despite the different response of the PBV ratio to exercise between normals and CAD patients, a significant overlap limits the value of this ratio as a discriminator of the presence, severity or location of CAD.

Key Words: Pulmonary blood volume, • exercise, • coronary artery disease.


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