Skip Navigation

European Heart Journal 1988 9(11):1250-1256;
Copyright © 1988 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by BEEN, M.
Right arrow Articles by MUIR, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BEEN, M.
Right arrow Articles by MUIR, A. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1988 The European Society of Carkology

Myocardial involvement in systemic lupus erythematosus detected by magnetic resonance imaging

M. BEEN*, B. J. THOMSON*, M. A. SMITH{dagger}, J. P. RIDGWAY{dagger}, R. H. B. DOUGLAS{ddagger}, M. BEEN*, J. J. K. BEST{ddagger} and A. L. MUIR*,

*Departments of Medicine Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, U.K.
{dagger}Departments of Medical Physics Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, U.K.
{ddagger}Departments of Medical Radiology Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, U.K.

Received 16 December 1987; revised 12 May 1988; .

Dr A. L. Muir, Department of Medicine, Royal Infirmary, Edinburgh EH39YW, U.K.

Abstract

Myocardial involvement in systemic lupus erythematosus is commonly found at autopsy but seldom recognized clinically or by routine cardiological investigations. As the magnetic resonance relaxation parameter, Tl, is altered by changes in tissue cellularity, we carried out magnetic resonance imaging in 10 patients with systemic lupus erythematosus. Five had active systemic lupus erythematosus when assessed using the lupus activity criteria count.

The mean ( ±SD) Tl was 319 ±12 in normal volunteers and 321 ± 10 in a second control group with hypertrophic cardiomyopathy. In the group with systemic lupus erythematosus, there was a higher mean value of 336 ms/vith a wider scatter of individual results (SD±22 ms). In the subgroup of patients with active disease, Tl was significantly higher (349 ± 24) than in either of the two control groups.

In addition, there was an inverse correlation between serum complement and myocardial Tl in patients with systemic lupus erythematosus. Myocardial abnormalities in systemic lupus erythematosus were demonstrated by magnetic resonance imaging even where other non-invasive cardiac investigations were negative. We conclude that Tl calculated from magnetic resonance imaging is often abnormal in systemic lupus erythematosus and probably indicates myocardial involvement.

Key Words: Relaxation parameter Tl, • Lupus activity criteria count.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 LupusHome page
H Abdel-Aty, N Siegle, A Natusch, E Gromnica-Ihle, R Wassmuth, R Dietz, and J Schulz-Menger
Myocardial tissue characterization in systemic lupus erythematosus: value of a comprehensive cardiovascular magnetic resonance approach
Lupus, June 1, 2008; 17(6): 561 - 567.
[Abstract] [PDF]

Home page
 RadiologyHome page
D. R. Messroghli, S. Plein, D. M. Higgins, K. Walters, T. R. Jones, J. P. Ridgway, and M. U. Sivananthan
Human Myocardium: Single-Breath-hold MR T1 Mapping with High Spatial Resolution--Reproducibility Study
Radiology, March 1, 2006; 238(3): 1004 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
J A Singh, P K Woodard, V G Davila-Roman, A D Waggoner, F R Gutierrez, J Zheng, and S A Eisen
Cardiac magnetic resonance imaging abnormalities in systemic lupus erythematosus: a preliminary report
Lupus, February 1, 2005; 14(2): 137 - 144.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.