Skip Navigation

European Heart Journal 1988 9(12):1303-1307;
Copyright © 1988 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by LEVI, G.
Right arrow Articles by QUADRI, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LEVI, G.
Right arrow Articles by QUADRI, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1988 The European Society of Cardiology

Coxsackie virus heart disease: 15 years after

G. LEVI, S. SCALVINI, M. VOLTERRANI, S. MARANGONI, G. AROSIO and A. QUADRI

Fondazione clinica del lavoro, Rehabilitation Medical Center Gussago (BS)
*Spain dali civili di Brescia, Cardiovascular Laboratory Italy

Received 16 December 1987; revised 14 June 1988; .

G.Levi M.D., Fondazione Clinica Del Lavoro, Centro Medico di Riabilitazione, 25064-Gussago (BS), Italy.

Abstract

From 1969 to 1973, 68 patients were admitted to the 4th Division of Medicine of the Brescia Civil Hospital with the diagnosis of viral myocarditis. The patients were divided into two groups according to the results of the Coxsackie virus complement fixing antibodies test: Group 1 (42 patients) with a fourfold or greater rising antibody titre: Group 2 (26 patients) with a negative serum test.

Both groups were examined after a follow-up period of 15 years. Ten patients from Group 1 died. The diagnoses were chronic myocarditis (three cases): chronic cardiomyopathy — pulmonary embolism (one case); chronic cardiomyopathy — liver cirrhosis (one case); dialted cardiomyopathy—sudden death (two cases); congestive cardiomyopathy (three cases). No Group 2 patients died. The 15-year mortality rate of Group I was significantly higher than that of Group 2 (Fisher Test;p<0.005).

In conclusion, the natural history of Coxsackie virus heart disease is characterized by two possibilities: a complete recovery from a clinical point of view, in some cases with only minor T wave abnormalities, or evolution into a chronic disease (dilated cardiomyopathy) having a high mortality rate within 10 years of the onset of the acute disease.

Key Words: Coxsackie virus, • myocarditis, • dilated myocardiopathy.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 HeartHome page
A D'Ambrosio, G Patti, A Manzoli, G Sinagra, A Di Lenarda, F Silvestri, and G Di Sciascio
The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy: a review
Heart, May 1, 2001; 85(5): 499 - 504.
[Full Text]

Home page
 J Am Coll CardiolHome page
S. Fujioka, Y. Kitaura, A. Ukimura, H. Deguchi, K. Kawamura, T. Isomura, H. Suma, and A. Shimizu
Evaluation of viral infection in the myocardium of patients with idiopathic dilated cardiomyopathy
J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1920 - 1926.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. R. Gebhard, C. M. Perry, S. Harkins, T. Lane, I. Mena, V. C. Asensio, I. L. Campbell, and J. L. Whitton
Coxsackievirus B3-Induced Myocarditis : Perforin Exacerbates Disease, But Plays No Detectable Role in Virus Clearance
Am. J. Pathol., August 1, 1998; 153(2): 417 - 428.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.