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European Heart Journal 1988 9(2):165-171;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Normal diastolic filling patterns of the left ventricle

I. VAN DAM, J. FAST, T. DE BOO, J. HOPMAN, A. VAN OORT, A. HERINGA, J. ALSTERS, T. VAN DER and O. DANIËLS

Interuniversity Cardiology Institute/University Hospital Nijmegen The Netherlands

Received 17 February 1987; revised 19 August 1987; .

address for correspondence: Ina van Dam, M.D., Interuniversity Cardiology Institute, P.O Box 19258, 3501 GV Utrecht, The Netherlands.

Abstract

Pulsed Doppler measurements on both sides of the mitral valve and M-mode left ventricular echocardiograms were performed in 215 healthy subjects, 120 males and 95 females, between one and 65 years old, in order to evaluate normal diastolic filling patterns of the left ventricle. The relation between the maximum blood velocity during early passive filling (Ewave) and during atrial contraction (A wave) was computed from the Doppler spectra obtained proximal and distal to the mitral valve, resulting in the EA ratio. The influence on the EA ratio of age, gender, body surface area, blood pressure, heart rate, PR interval, respiration, wall thickness and basal wall mass of the left ventricle was investigated.

The study showed that the EA ratio measured proximal to the mitral valve (in the left atrium) was significantly smaller than the EA ratio measured distal (in the left ventricle) and that the only prominent relations with the EA ratio were those with age and heart rate. The EA ratio declines with age: proximal to the mitral valve from approximately (medians) 2.5 to 1 and distal to it from 3.5 to 1.5. All other physiological variables are weakly related or unrelated to the EA ratio in this group of healthy subjects.

Key Words: Mitral valve • pulsed Doppler echocardiography • healthy subjects • EA ratio


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