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European Heart Journal 1988 9(2):215-222;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Mortality in various intervention trials in elderly hypertensive patients: A review*

J. STAESSEN, R. FAGARD, R.VAN HOOF and A. A"MERY

Hypertension and Cardiovascular Rehabilitation Unit, Department of Pathophysiology, University of Leuven Belgium

address for correspondence: J. Staessen, M.D., Klinisch Laboratorium Hypertensie, U.Z. Gasihuisbcrg, Hercstraat 49, B-3000 Leuvcn, Belgium.

Abstract

Results on total and cause-specific mortality from various randomized intervention trials on antihypertensive drug treatment in elderly hypertensives are reviewed, compared and pooled. Mortality from all causes tended to decrease in all trials, but this decrease was not statistically significant in any of the trials separately, nor when all results were pooled. When the results of all the trials were combined, there was a significant overall decrease in cardiovascular mortality of 28%. This decrease in cardiovascular mortality was mainly related to a significant reduction in cerebrovascular mortality of 41%. Mortality from coronary heart disease also tended to decrease by 28%, but statistical significance was not reached.

Key Words: Antihypertensive drug treatment • elderly • hypertension


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