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European Heart Journal 1988 9(2):228-234;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Integrated reporting of quality and length of life-A statistician's perspective*

S. M. GORE

MRC Biostatistics Unit 5 Shaftesbury Road, Cambridge CB2 2BW, U.K.

Abstract

The reporting of trials has been dominated by a concentration on single measures of response, such as survival or extent of side-effects, perhaps selected as giving an impressive P value for treatment comparisons. Relevant questions about trade-offs are seldom answered or even envisaged in the trial design. Cardiovascular trials should provide evidence on quality of life after myocardial infarction or during antihypertensive therapy. Examples from oncology are used to illustrate how the robustness of treatment recommendation can be explored through a grid of quality adjustments, ranging from complete intolerance of side-effects to absolute acceptance of them. Treatment recommendations may need to be specific to patients unless they are independent of the system of quality adjustment used.

Key Words: Quality of life • specialty endorsement • quality-adjusted life years


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