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European Heart Journal 1988 9(3):271-278;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Electrophysiological effects of intravenous nicaïnoprol, a new antiarrhythmic agent, in 11 patients

C. C. LIBERSA*,, J. F. CARON*, S. KACET{dagger}, J. DAGANO{dagger}, A. VINCENT*, B. DUPUIS*, J . L. GAYET* and J. P. LEKJEFFRE{dagger}

*Hospital Pharmacology Laboratory, Faculte de Médecine 1 place de Verdun, 59045 LILLE Cedex,
{dagger}Department of Cardiology A, Hôpital Cardiologique, Boulevard du Professeur J. Leclercq 59037 LILLE Cedex, France

revised 11 September 1987; .

reprint requiests to: Professeur J. Lekieffre, Service De Cardoilogie A Hopital Cardiologique, Boulevard du Professeur J. Leclercq, 59037 LILLE cedex, france

Abstract

Nicainoprol, a new class 1 antiarrhythmic drug was given intravenously in a dose of 2 mg kg of body weight (two patients) and 3 mg kg–1 of body weight (nine patients), and the clinical, electrocardiographic and electrophysiological effects were studied. Fifteen minutes after the end of drug administration, the PR interval was prolonged by 24–4% (P<0.001), and the QTC by 3.9% (P<0.01). The prolongation of QRS duration ( + 6%) was not significant. There was a slight ( – 3–9%) but non-significant decrease of the heart rate, with no alteration in sinus node function. Alteration of atrial conduction and atrioventricular (AV) conduction were due to an increase in the PA interval ( + 57.4%, P< 0.05), the AH interval ( +10.9%, NS) and the HV interval (+ 43.8%, Y<0.01). The anterograde Wenckebach cycle length increased by 11% (P<0.01). The effective and functional atrial refractory periods increased respectively by 4–5% and 114% (P<0–05), and the effective refractory period of the A Vnode increased by 11–2% (P < 005). None of the other electrophysiological variables changed significantly. A non-significant drop in blood pressure was noted between the second minute following injection ( – 9–4%) and the 15th minute ( - 3–4%), and two patients complained of dizziness; one of these two patients reported a heat flush with an oral burning. In conclusion, nicainoprol seems to possess the electrophysiological properties of some other class I antiarrhythmic drugs, and is clinically well tolerated.

Key Words: Nicainoprol • antiarrhythmic • electrophysiology.


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