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European Heart Journal 1988 9(3):291-294;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Risk factors for stroke in chronic atrial fibrillation

P. PETERSEN and J. GODTFREDSEN

Department of Cardiology, Herley University Hospital and Department of Neurology, University Hospital Rigshospitalet Copenhagen, Denmark

Received 3 July 1987; revised 18 September 1987; .

address for correspondence: Palle Petersen, M.D., Department of Neurology, University Hospital, Rigshospitalet, 9, Blegdamsvej, DK-2100 Copenhagen, Denmark.

Abstract

Atrial fibrillation is associated with an increased risk of stroke. Different risk factors may be of importance regarding stroke incidence and mortality in atrial fibrillation. Retrospectively, we studied 786 patients with chronic atrial fibrillation, 229 with rheumatic heart disease and 557 without. In all, 127 patients had stroke (16%). Using Cox's proportional hazard model for failure-time data with age, gender, etiology, degree of heart failure and cardiac enlargement as explanatory (independent) variables, only etiology (rheumatic heart disease) was a significant risk factor for stroke (P<0.006). Significant risk factors for death in 653 patients without stroke were age (P= 0.000) and congestive heart failure at the onset of atrial fibrillation (P = 0.000). The need to identify other risk factors for stroke in patients with atrial fibrillation is emphasized, for selecting patients at high risk for prophylactic treatment with anticoagulants or aspirin.

Key Words: Stroke • atrial fibrillation


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