Copyright © 1988 by the European Society of Cardiology.
© 1988 The European Society of Cardiology
Quantitative analysis of the signal-averaged QRS in patients with arrhythmogenic right ventricular dysplasia
1Division of Cardiology, Medical Department I. Sahigren's Hospital Gothenburg, Sweden
Received 9 June 1987; revised 25 August 1987; .
address for reprints Dr Carina Blomstrom-Lundqvisl, M.D., Division of Cardiology, Medical Department I, Sahlgren’s Hospital, S-413 45 Goieborg, Sweden.
Abstract
Temporal signal averaging of the surface QRS (VI + V3 + V5) was performed in 16 patients with arrhythmogenic right ventricular dysplasia and in 16 normal subjects. The differences between ARVD patients and normals were large for the filtered QRS duration (FQRSd) (146.2±18.9 vs. 91.8±4.1ms, P<000001), the late potential duration (LPd) (83.5±23.3 ms vs. 23.6±4.6ms, P< 0.00001), the LPd/ FQRSd ratio (53.9± 10.1% vs. 25.8±5.1%, P <0.00001), the filtered QRS amplitude (234.0±61.1µV vs. 429±942 fiV, P <0001), and the root mean square voltage of the signals in the terminal 40 and 50 ms of the FQRS (RMS40 and RMS50) (18.4± 10.0µV vs. 118.4±49.8p.V, P<0.0005 and 27.9± 19.2µV vs. 217.0±66.3fiV, P<0000002). RMS50 <40µV discriminated best between ARVD and normals (81% sensitivity and 100% specificity). The right-sided predominance of the abnormalities in ARVD was demonstrated by the significantly longer FQRSd and LPd, and the higher ratio LPd/FQRSd in right than in left precordial leads. The arrhythmia susceptibility did not seem to influence the presence of or properties ofLP in the ARVD group. Patients with multiple QRS morphologies during ventricular tachycardia (VT) had, compared with patients with only one type of VT, longer LPd (108.3 ±46.4 ms vs. 64.2 ±31.7 ms, P<0.02) and lower RMS40 voltage (9.4±9.9 µV vs. 25.4±21.6 µV, P<0.05). The relative heart volume was positively correlated with delayed activity, but an enlarged heart was not apre-requisitefor the presence ofLP. The method thus identifies changes which are specific to ARVD. The findings indicate that certain electrical or morphological conditions are required for the occurrence of arrhythmias.
Key Words: Signal-averaging • ventricular tachycardia • arrhythmogenic right ventricular dysplasia
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