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European Heart Journal 1988 9(3):313-318;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Doppler echocardiographic estimation of cardiac output: analysis of temporal variability

S. C. ROBSON*,, R. J. BOYS{dagger} and S. HUNTER*

*Department of Paediatric Cardiology, Freeman Hospital, Newcastle Upon Tyne U.K.
{dagger}Department of Statistics, University of Newcastle Upon Tyne U.K.

Received 10 July 1987; revised 2 September 1987; .

Correspondence to: Stephen Robson, Department of Paediatric Cardiology, Freeman Hospital, Freeman Road, High Heaton, Newcastle Upon Tyne NE7 7DN, U.K

Abstract

The temporal variability of combined cross-sectional and Doppler echocardiographic estimates of cardiac output was studied in 14 normal subjects. In each subject cross-sectional echocardiographs and Doppler velocities were recorded from the aortic, pulmonary and mitral valves. Recordings were repeated after 30–60 min and after 1–3 months to allow estimation of short-term and long-term temporal variability.

A components of variance analysis showed that between-subject variability was significantly larger than within-subject variability for all measured and calculated variables. Long-term variability was larger than short-term variability for all variables except the mitral valve area. Calculation of flows from the three measurement sites were equally reproducible and the mean percentage error for CO measurements performed 1–3 months apart ranged from 6.4% to 7.4%. The 95% confidence intervals for Doppler measurements of CO at the three sites ranged from ±0.491 min–1 to ± 0.561 min–1, suggesting that the temporal variability of flow measurements using the non-invasive Doppler method is sufficiently small for the method to be useful in serial haemodynamic studies.

Key Words: Doppler echocardiography • cardiac output • reproducibility


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