Copyright © 1988 by the European Society of Cardiology.
© 1988 The European Society of Cardiology
Secondary prevention reinfarction Israeli nifedipine trial (SPRINT).
A randomized intervention trial of nifedipine in patients with acute myocardial infarction
THE ISRAELI SPRINT STUDY GROUPReceived 17 September 1987; revised 24 November 1987; .
Address for correspondence: S. Behar. M.D., Director, SPRINT Coordinating Centre, Heart Institute, Sheba Medical Centre, Tel Hashomer 52621, Israel
Abstract
The efficacy of nifedipine in the prevention of post-infarction morbidity and mortality was evaluated in a double-blind clinical trial of 2276 survivors of acute myocardial infarction recruited from the cardiac departments of 14 Israeli hospitals. The patients were randomized to either nifedipine 30 mg day–1 or placebo between 7 and 21 days after their hospitalization for the acute event. Baseline characteristics of patients in each group were virtually identical for most pertinent variables.
Mortality during an average 10-month follow-up period was 5.7% in the placebo group and 5.8% among those receiving nifedipine. Nonfatal recurrent myocardial infarction occurred in 4.8% and 4.4% of placebo and nifedipine patients, respectively. Administration of nifedipine according to the protocol used in the present study had no effect on cardiac events in survivors of acute myocardial infarction.
Key Words: Secondary prevention • nifedipine • multicentre studies • calcium antagonists
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Cucherat Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials Eur. Heart J., December 2, 2007; 28(24): 3012 - 3019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E van der Elst, H. Buurma, M. L Bouvy, and A. de Boer Drug Therapy for Prevention of Recurrent Myocardial Infarction Ann. Pharmacother., October 1, 2003; 37(10): 1465 - 1477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Kizer and S. E. Kimmel Epidemiologic Review of the Calcium Channel Blocker Drugs: An Up-to-date Perspective on the Proposed Hazards Arch Intern Med, May 14, 2001; 161(9): 1145 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.Y.H. Lip, C. Lydakis, and D.G. Beevers Management of patients with myocardial infarction and hypertension Eur. Heart J., July 2, 2000; 21(14): 1125 - 1134. [PDF]
|
|
|
|
 |
|
 S. S. Rathore, A. K. Berger, K. P. Weinfurt, K. A. Schulman, W. J. Oetgen, B. J. Gersh, and A. J. Solomon Acute Myocardial Infarction Complicated by Atrial Fibrillation in the Elderly : Prevalence and Outcomes Circulation, March 7, 2000; 101(9): 969 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S Gottlieb, U Goldbourt, V Boyko, D Harpaz, L Mandelzweig, Z Khoury, S Stern, S Behar, and for the SPRINT and Israeli Thrombolytic Survey Gro Mortality trends in men and women with acute myocardial infarction in coronary care units in Israel. A comparison between 1981-1983 and 1992-1994 Eur. Heart J., February 2, 2000; 21(4): 284 - 295. [Abstract] [PDF]
|
|
|
|
|
|
C. D. Frances, A. S. Go, K. W. Dauterman, K. Deosaransingh, D. L. Jung, S. Gettner, J. M. Newman, B. M. Massie, and W. S. Browner Outcome Following Acute Myocardial Infarction: Are Differences Among Physician Specialties the Result of Quality of Care or Case Mix? Arch Intern Med, July 12, 1999; 159(13): 1429 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Kaufmann, J. Frielingsdorf, L. Mandinov, C. Seiler, R. Hug, and O. M. Hess Reversal of Abnormal Coronary Vasomotion by Calcium Antagonists in Patients With Hypercholesterolemia Circulation, April 14, 1998; 97(14): 1348 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H Mehta and K. A Eagle Fortnightly review: Secondary prevention in acute myocardial infarction BMJ, March 14, 1998; 316(7134): 838 - 842. [Full Text]
|
|
|
|
|
|
D. B. Miller Secondary Prevention for Ischemic Heart Disease: Relative Numbers Needed to Treat With Different Therapies Arch Intern Med, October 13, 1997; 157(18): 2045 - 2052. [Abstract] [PDF]
|
|
|
|
|
|
K. Ishikawa, S. Nakai, T. Takenaka, K. Kanamasa, J. Hama, I. Ogawa, T. Yamamoto, M. Oyaizu, A. Kimura, K. Yamamoto, et al. Short-Acting Nifedipine and Diltiazem Do Not Reduce the Incidence of Cardiac Events in Patients With Healed Myocardial Infarction Circulation, May 20, 1997; 95(10): 2368 - 2373. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. H. Hennekens, C. M. Albert, S. L. Godfried, J. M. Gaziano, and J. E. Buring Adjunctive Drug Therapy of Acute Myocardial Infarction -- Evidence from Clinical Trials N. Engl. J. Med., November 28, 1996; 335(22): 1660 - 1668. [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Jukema, A. H. Zwinderman, A. J. van Boven, J. H.C. Reiber, A. Van der Laarse, K. I. Lie, and A. V.G. Bruschke Evidence for a Synergistic Effect of Calcium Channel Blockers With Lipid-Lowering Therapy in Retarding Progression of Coronary Atherosclerosis in Symptomatic Patients With Normal to Moderately Raised Cholesterol Levels Arterioscler Thromb Vasc Biol, March 1, 1996; 16(3): 425 - 430. [Abstract] [Full Text]
|
|
|
|
|
|
N. F. Col, T. J. McLaughlin, S. B. Soumerai, D. W. Hosmer Jr, J. Yarzebski, J. H. Gurwitz, J. M. Gore, and R. J. Goldberg The Impact of Clinical Trials on the Use of Medications for Acute Myocardial Infarction: Results of a Community-Based Study Arch Intern Med, January 8, 1996; 156(1): 54 - 60. [Abstract] [PDF]
|
|
|
|
|
|
L. H. Opie and F. H. Messerli Nifedipine and Mortality : Grave Defects in the Dossier Circulation, September 1, 1995; 92(5): 1068 - 1073. [Full Text]
|
|
|
|
|
|
S. Yusuf Calcium Antagonists in Coronary Artery Disease and Hypertension : Time For Reevaluation? Circulation, September 1, 1995; 92(5): 1079 - 1082. [Full Text]
|
|
|
|
|
|
C. D. Furberg, B. M. Psaty, and J. V. Meyer Nifedipine : Dose-Related Increase in Mortality in Patients With Coronary Heart Disease Circulation, September 1, 1995; 92(5): 1326 - 1331. [Abstract] [Full Text]
|
|
|
|
|
|
J. Z. Ayanian, P. J. Hauptman, E. Guadagnoli, E. M Antman, C. L. Pashos, and B. J. McNeil Knowledge and Practices of Generalist and Specialist Physicians Regarding Drug Therapy for Acute Myocardial Infarction N. Engl. J. Med., October 27, 1994; 331(17): 1136 - 1142. [Abstract] [Full Text]
|
|
|
|
|
|
P. C. Deedwania and E. V. Carbajal Secondary Prevention After Myocardial Infarction: Too Many Choices, Which Ones Work? Arch Intern Med, February 8, 1993; 153(3): 285 - 288. [Abstract] [PDF]
|
|
|
|
|
|
U. Goldbourt, S. Behar, H. Reicher-Reiss, M. Zion, L. Mandelzweig, and E. Kaplinsky Early Administration of Nifedipine in Suspected Acute Myocardial Infarction: The Secondary Prevention Reinfarction Israel Nifedipine Trial 2 Study Arch Intern Med, February 8, 1993; 153(3): 345 - 353. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Eldar, Z. Sievner, U. Goldbourt, H. Reicher-Reiss, E. Kaplinsky, S. Behar, and SPRINT Study Group Primary Ventricular Tachycardia in Acute Myocardial Infarction: Clinical Characteristics and Mortality Ann Intern Med, July 1, 1992; 117(1): 31 - 36. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Yusuf, J. Wittes, and L. Friedman Overview of Results of Randomized Clinical Trials in Heart Disease: I. Treatments Following Myocardial Infarction JAMA, October 14, 1988; 260(14): 2088 - 2093. [Abstract] [PDF]
|
|