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European Heart Journal 1988 9(5):498-502;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Haemodynamic effects of DPI 201–106, following single intravenous dose administration to patients with moderate cardiac failure

J. C. HOGAN*,§, R. A. GREENBAUM*,||, M. W. LUNNON{ddagger}, A. J. W. HILSON{dagger} and T. R. EVANS*

*Department of Cardiology, The Royal Free Hospital & School of Medicine London NW 3 2QG
{dagger}Department of Nuclear Medicine and Medical Physics, The Royal Free Hospital & School of Medicine London NW3 2QG
{ddagger}Clinical Research Unit London Sandoz Ltd, Feltham, Middlesex TW13 4EP, U.K.

Received 19 June 1987; revised 20 August 1987; .

||Present address and address for correspondence Dr R. A. Greenbaum, Department of Cardiology, Edgware Hospital, Edgware, Middlesex HA8 0A0, U.K.

Abstract

DPI 201–106 is a novel compound unrelated to other cardioactive agents and has been shown to have an inotropic effect in animal preparations. The drug was given by intravenous infusion (20 mg over 10 min) to 10 patients with moderate cardiac failure and the haemodynamic effects measured at intervals up to 1 h following infusion. Maximal effects were seen immediately following the infusion of DPI 201–106. Cardiac index showed an increase from baseline 2·72 (0·16) 1 min-1 m-2 to 3·18 (0.21) 1 min-1 m-2 at the end of infusion (P<0·001). Subsequent values were not significantly raised. Pulmonary capillary wedge pressure and pulmonary artery pressure fell from 27·6 (3·2) and 36·9 (4·4) to 15·3 (3·6) and 24·2 (4·9) mmHg, respectively (P<0·001 in both cases). A statistically significant effect on cardiac index was not seen at 1 h. However, pulmonary pressures remained reduced at this point. Radionuclide ejection fraction showed a significant increase from 15·4 (1·5) to 21·9 (2·2)% (P<0·005) at the end of infusion, and maintained a significant increase at 1 h. Having demonstrated beneficial, acute haemodynamic effects in this study, further work should be undertaken with DPI 201–106 to investigate the effect of chronic treatment in patients with cardiac failure.

Key Words: DPI 201–106 • inotrope • cardiac failure • haemodynamics • radionuclide ventriculography


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