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European Heart Journal 1988 9(5):552-556;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Acute vascular toxicity after combination chemotherapy with cisplatin, vinblastine, and bleomycin for testicular cancer

T. STEFENELLI*, R. KUZMITS{dagger}, W. ULRICH{ddagger} and D. GLOGAR*

*Departments of Cardiology, University of Vienna Vienna, Austria
{dagger}Medicine II, University of Vienna Vienna, Austria
{ddagger}Department of Pathology, University of Vienna Vienna, Austria

Received 7 July 1987; revised 23 October 1987; .

Address for correspondence: Dr Thomas Stefenelli, Department of Cardiology, University of Vienna Garnisongasse 13, A 1090 Vienna, Austria

Abstract

Twenty-one consecutive patients with testicular cancer treated with bleomycin, vinblastine, and cisplatin (PVB) were evaluated for acute vascular ischaemic events during chemotherapy. Angina pectoris occurred in 8/21 (38%) patients, a median 5·6 weeks after initiation of chemotherapy and persisted for 2·7 days. Raynaud's phenomenon was detected in seven (33%) subjects, transient ischaemia of the toes was found in six (29%) patients, one patient complained of migraine, but none had major cerebrovoscular accidents. Patientswith and without angina pectoris and/or Raynaud's phenomenon did not differ in respect of age, histology of tumor or medication. Ischaemia occurred at any time during the course of chemotherapy. No correlation was found between dosage of drugs and time of onset of ischaemic reactions. However, arterial occlusive event is a frequent and common toxicity and a result of treatment with PVB.

Key Words: Angina pectoris • Raynaud's phenomenon • vascular toxicity • combination chemotherapy


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