Copyright © 1988 by the European Society of Cardiology.
© 1988 The European Society of Cardiology
Acute conversion of atrial fibrillation to sinus rhythm: clinical efficacy of flecainide acetate. Comparison of two regimens
Departments of Cardiology Oostersingel 59, 9713 EZ Groningen, The Netherlands
*Department of Clinical Pharmacology, University Hospital Groningen Oostersingel 59, 9713 EZ Groningen, The Netherlands
Received 13 July 1987; revised 26 November 1987; .
Harry J. G M. Crijns. Department of Cardiology. University Hospital Groningen, Oostersingel 59. 9713 EZ Groningen. The Netherlands.
Abstract
The efficacy and safety of oral (up to 400 mg in 3 h) and intravenous regimens (up to 150 mg in 10 min) of flecainide acetate were compared in the acute conversion of atrial fibrillation to sinus rhythm. Acute conversion was defined as conversion occurring within 5 h (oral) or within 30 min (intravenous regimen). Following classification in recent onset (duration < 24 h) atrial fibrillation (n = 27) and chronic ( > 24 h) atrial fibrillation (n = 13), patients were randomly assigned to one of the two regimens. In the group of patients with recent onset atrial fibrillation, 10 out of 14 (oral treatment) and 10 out of 13 (intravenous treatment) responded acutely. Approximately half of responding patients converted after the first oral dose or within the infusion time. In contrast, no patient with chronic atrial fibrillation showed conversion on flecainide. No serious adverse effects were encountered with the regimens used, not even in patients concomitantly using digitalis or verapamil. Thus, patients with recent onset atrial fibrillation can safely be converted to sinus rhythm using oral or intravenous regimens of flecainide.
Key Words: Atrial fibrillation • acute conversion • flecainide
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