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European Heart Journal 1988 9(6):639-641;
Copyright © 1988 by the European Society of Cardiology.
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© 1988 The European Society of Cardiology

Atrial natriuretic peptide in atrial fibrillation before and after electrical cardioversion therapy

P. PETERSEN, J. KASTRUP, R. VILHELMSEN and H. J. SCHÜTTEN

Departments of Neurology and Cardiology, University Hospital Rigshospitalet, Department of Cardiology Kommunehospitalet, Copenhagen and Department of Medical Physiology C, University of Copenhagen Denmark

Received 9 July 1987; revised 27 November 1987; .

Abstract

In eight patients with atrial fibrillation of less than 3 months duration and without congestive heart failure the plasma concentration of atrial natriuretic peptide was determined one day before, the day after and again 30 days after electrical cardioversion therapy. The pretreatment plasma concentration of the peptide was 99 pg mg–1 (23–480, median and range). The day after cardioversion to sinus rhythm the peptide concentration had normalized to 36 pg ml–1 (18–151). The plasma concentration of atrial natriuretic peptide remained stable in all but one patient for a period of 30 days (46 pg ml–1, 16–695) (P = 0·03).

In conclusion, the plasma concentration of atrial natriuretic peptide in patients with atrial fibrillation was significantly reduced after electrical cardioversion to sinus rhythm and remained stable for a period of 30 days.

Key Words: Atrial fibrillation • atrial natriuretic peptide


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