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European Heart Journal Advance Access published online on December 9, 2008

European Heart Journal, doi:10.1093/eurheartj/ehn531
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Self-estimated physical functioning poorly predicts actual exercise capacity in adolescents and adults with congenital heart disease

Alexander Gratz, John Hess and Alfred Hager*

Department of Pediatric Cardiology and Congenital Heart Disease, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, D-80636 München, Germany

Received 19 March 2008; revised 16 October 2008; accepted 18 November 2008.

* Corresponding author. Tel: +49 89 1218 1650, Fax: +49 89 1218 3013, Email: alexander.gratz{at}o2online.de; Hager{at}dhm.mhn.de

Aims: The aim of this study is to compare self-reported health-related quality-of-life (HRQoL) with the objective of exercise performance in patients with congenital heart disease (CHD) according to diagnosis.

Methods and results: 564 patients (255 females, 14–73 years) with various CHD (62 shunt, 66 left heart obstruction, 33 PS/PR, 47 Ebstein, 96 Fallot, 98 TGA after atrial switch, 38 other TGA, 31 Fontan, 32 palliated/native cyanotic, 61 others) and a group of 53 healthy controls (18 females, 14–57 years) completed a QoL questionnaire (SF-36) and performed a symptom-limited cardiopulmonary exercise test. Despite several limitations at exercise (P = 1.30 x 10–33), patients only reported reductions in HRQoL concerning physical functioning (P = 4.41 x 10–15) and general health (P = 6.17 x 10–5) and not psychosocial aspects. This could be confirmed in all diagnostic subgroups. Correlation to peak oxygen uptake was found in physical functioning (r = 0.435, P = 1.72 x 10–27) and general health (r = 0.275, P = 3.79 x 10–11). However, there was severe overestimation of physical functioning in most patients when compared with actual exercise test results.

Conclusion: Patients with CHD rate their HRQoL impaired only in physical functioning and general health and not in any psychosocial aspect. Self-estimated physical functioning poorly predicts actual exercise capacity.

Key Words: Congenital heart disease • Quality of life • Cardiopulmonary exercise testing


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S. Glaser, C. Schaper, R. Ewert, and B. Koch
Peak oxygen uptake and exercise capacity: a reliable predictor of quality of life?
Eur. Heart J., July 1, 2009; 30(13): 1674 - 1674.
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Home page
Eur Heart JHome page
A. Gratz, J. Hess, and A. Hager
Peak oxygen uptake and exercise capacity: a reliable predictor of quality of life?: reply
Eur. Heart J., July 1, 2009; 30(13): 1674 - 1675.
[Full Text] [PDF]



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