The paradox of increased natriuretic hormones in congestive heart failure patients: Does the endocrine heart also fail in heart failure?

doi:10.1016/S0195-668X(03)00283-5

European Heart Journal 2003 24(16):1471-1472; doi:10.1016/S0195-668X(03)00283-5
Copyright © 2003 by the European Society of Cardiology.

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Editorial

The paradox of increased natriuretic hormones in congestive heart failure patients: Does the endocrine heart also fail in heart failure?

Jens Peter Goetze^a,b^,*, Jens Kastrup^b and Jens F Rehfeld^a

^a Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
^b Medical Department B, Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

^* Correspondence to: Jens Peter Goetze, MD, Department of Clinical Biochemistry, KB 3014, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. Tel.: +45-3545 3013; fax: +45-35454640
E-mail address: JPG@dadlnet.dk

Received 10 January 2003; accepted 7 May 2003

The first 10% of the full text of this article appears below.

The normal heart secretes Atrial Natriuretic Peptide (ANP) andBrain Natriuretic Peptide (BNP) from the atria, which counteractcardiac overload by stimulating renal natriuresis and loweringsystemic blood pressure.¹On a cellular level, the endocrinecapacity of the atria is reflected by the presence of secretorygranules for peptide storage, which almost 50 years ago gavethe first clue to the discovery of the endocrine heart.²Cardiacnatriuretic peptides are stored in secretory granules and secretedupon relevant stimuli such as stretch of the atrial myocytes.³Whenthe function . . . [Full Text of this Article]

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