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European Heart Journal 2003 24(2):136-137; doi:10.1016/S0195-668X(02)00798-4
Copyright © 2003 by the European Society of Cardiology.
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Editorial

Cardiac markers in acute coronary syndromes—refining our knowledge

R.M Califf*

Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, P.O. Box 17969, Durham, NC 27715, USA

Received October 22, 2002; accepted October 23, 2002 * Tel.: +1-919-668-8820; fax: +1-919-668-7103
calif001@mc.duke.edu

The first 10% of the full text of this article appears below.

See doi:10.1016/S1095-668X(02)00322-6and doi:10.1053/S1095-668X(02)00312-2for thearticles to which this editorial refers.

Just a few years ago, we appeared to be stymied in advancing the ability to predict outcomes in patients with acute coronary syndromes (ACS). A combination of refined clinical observation,advances in measurement of pathobiology, and large studies with expert application of statistical methods, however, has advanced this field beyond the ability of the clinical world to keep pace. Inthe last 5 years, the troponins,1–3 better clinical statistical models,4–6 C-reactive protein (CRP),7 and brain natriuretic peptide (BNP)8 have . . . [Full Text of this Article]


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