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European Heart Journal 2003 24(3):221-224; doi:10.1016/S0195-668X(02)00694-2
Copyright © 2003 by the European Society of Cardiology.
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Editorial

Mitochondria and the heart

L Bindoff*

The Institute of Neurology, Haukeland Sykehus, Bergen, Norway

* Tel.: +47-55975096; fax: +47-55975165
laurence.bindoff@helse-bergen.no

The first 150 words of the full text of this article appear below.

See doi:10.1016/S1095-668X(02)00387-1for thearticle to which this editorial refers.

Mitochondria are the major site of energy production in the cell. It is not surprising, therefore, that an energy dependant tissue such as heart is affected by mitochondrial dysfunction. In this issue, Holmgren and colleagues1 report the cardiological findings and clinical course of 17 children with cardiomyopathy identified from a large cohort of children with mitochondrial disease. This is an important study that provides essential information concerning the cardiological features of what are becoming increasingly common disorders. Moreover, it is one of the first studies to provide some information about the natural history of cardiac disease in this group.

Mitochondrial disease in the context of this study means disease arising from defects of the mitochondrial respiratory chain (MRC). The MRC consists of five multi-subunit complexes embedded in the inner mitochondrial membrane. Its function is to conserve the energy released by the oxidativemetabolism . . . [Full Text of this Article]


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Related articles in EHJ:

Cardiomyopathy in children with mitochondrial disease: Clinical course and cardiological findings
D Holmgren, H Wåhlander, B.O Eriksson, A Oldfors, E Holme, and M Tulinius
EHJ 2003 24: 280-288. [Abstract] [Full Text]  



This article has been cited by other articles:


Home page
 Annals of Clinical & Laboratory ScienceHome page
E. Fosslien
Mitochondrial Medicine - Cardiomyopathy Caused by Defective Oxidative Phosphorylation
Ann. Clin. Lab. Sci., October 1, 2003; 33(4): 371 - 395.
[Abstract] [Full Text] [PDF]