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European Heart Journal 2003 24(5):404-411; doi:10.1016/S0195-668X(02)00633-4
Copyright © 2003 by the European Society of Cardiology.
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Review article

Progenitor and embryonic stem cell transplantation for myocardial angiogenesis and functional restoration

Y Schwartza and R Kornowskib,*

a Cardiology Division, Rambam Medical Center, Haifa, Israel
b Cardiology Department, Rabin Medical Center, Petach-Tikva, Israel

* Corresponding author. Tel.: +972-3-937-6441; fax: +972-3-937-6438
E-mail address: rkornowski@clalit.org.il

Received 23 May 2002; revised 26 August 2002; accepted 28 August 2002

Key Words: Myocardial infarction • Cell transplantation • Progenitor cells

The first 150 words of the full text of this article appear below.

1. Introduction

The discovery of the main risk factors, the development of potent new drugs and sophisticated procedures and interventions, have not yielded the expected ‘victory’ over coronary heart disease. In fact, as the number of heart attacks decreases, the number of patients with refractory myocardial ischaemia and congestive heart failure is rapidly on the rise. Hence, novel therapeutic approaches are urgently required.

The concept of regenerative medicine using the body's own stem cells and growth factors to repair tissues is gradually coming closer to reality. Work regarding stem cells is ever increasing and is paving the way for medical repairs, including mending a damaged heart. This review aims to track recent developments in myocardial cell transplantation techniques.

2. What are stem cells? Terminology nomenclature

Every somatic or bodily cell in a human being possesses the full genetic code that makes us who we are. As we grow, however, our somatic cells become specialized or differentiated and they shut . . . [Full Text of this Article]

3. Does the human heart regenerate?

4. Angiogenesis and arteriogenesis

5. What could possibly be achieved using cell therapy?

6. Utilization of stem cells for myocardial regeneration

7. Utilization of progenitor cells for myocardial angiogenesis

8. Non stem cell sources for myocardial regeneration

9. Initial experiences in patients

10. What is still required and open questions

11. Conclusions


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