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European Heart Journal 2003 24(7):583-585; doi:10.1016/S0195-668X(02)00817-5
Copyright © 2003 by the European Society of Cardiology.
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Editorial

In-stent restenosis: intracoronary ß-radiation at the crossroads

R Seabra-Gomes

Hospital de Santa Cruz, Institute do Corção, Av. Prof. Reynaldo Dos Santos, Carnaxide Linda-a-Velha, 2795 Lisbon, Portugal

E-mail address: seago@esoterica.pt

The first 10% of the full text of this article appears below.

See doi:10.1016/S1095-668X(02)00617-6for thearticle to which this editorial refers.

In-stent restenosis, particularly of the diffuseand proliferative types, remains a major concern after percutaneous coronary interventions. Smooth muscle cells proliferation has been considered the main constituent of early restenotic plaques and there is evidence that late extracellular matrix production and chronic inflammation can also occur.1 The incidence of recurrent in-stent restenosis is known to be much higher than after initial stent placement and relates with longer lesion or stent length, smaller vessel diameter, saphenous vein grafts, presence of diabetes, etc.2

If vascular radiation is controversial for patients with de novo lesions,3 several randomized clinical trials of intracoronary brachytherapy for in-stent restenosis already published,4–9 have confirmed that . . . [Full Text of this Article]


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