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European Heart Journal 2004 25(12):999-1000; doi:10.1016/j.ehj.2004.04.020
Copyright © 2004 by the European Society of Cardiology.
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Editorial

Stem cells in unstable angina: the dynamic duo

Divaka Perera, Gajen Kanaganayagam and Michael Marber*

The Cardiovascular Division, Department of Cardiology, GKT School of Medicine, KCL, The Rayne Institute, St Thomas' Hospital, London, UK

* Correspondence to: Prof. M. Marber, The Cardiovascular Division, Department of Cardiology, GKT School of Medicine, KCL, The Rayne Institute, St Thomas' Hospital, London, UK. Tel.: +44-207-188-1008; fax: +44-207-188-0970
E-mail address: mike.marber@kcl.ac.uk

The first 10% of the full text of this article appears below.

This editorial refers to "Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation"1 by J. George on page 1003

The embryonic vascular system in vertebrates is derived from pluripotent stem cells, known as haemangioblasts, by a process termed vasculogenesis. A much more limited form of new vessel growth, angiogenesis, occurs post-natally and was thought to involve the proliferation and migration of fully differentiated cells from existing blood vessels. However, this traditional paradigm has been called into question by the discovery of a subpopulation of circulating immature mononuclear cells which differentiate into endothelial cells in vitro and contribute to angiogenesis in vivo.1 A growing body of evidence suggests that these endothelial progenitor cells (EPCs) are mobilised from the bone marrow and contribute to new vessel growth in vascular trauma, organ ischaemia . . . [Full Text of this Article]


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Related articles in EHJ:

Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation
Jacob George, Emil Goldstein, Soulico Abashidze, Varda Deutsch, Haim Shmilovich, Ariel Finkelstein, Itzhak Herz, Hylton Miller, and Gad Keren
EHJ 2004 25: 1003-1008. [Abstract] [FREE Full Text]  



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