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European Heart Journal 2004 25(17):1475-1476; doi:10.1016/j.ehj.2004.07.015
Copyright © 2004 by the European Society of Cardiology.
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Editorial

TIMPs, MMPs and cardiovascular disease

Franz H. Messerli*

Ochsner Clinic Foundation, New Orleans, Louisiana, USA

* Correspondence to: Franz H. Messerli, M.D., Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA. Tel.: +1 504 842 3144; fax: +1 504 842 4220 (E-mail: fmesserli@aol.com).

The first 10% of the full text of this article appears below.

This editorial refers to "Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study"{dagger} by J. Sundstrรถm et al. on page 1509

The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that cleave the extracellular matrix and have been shown to be regulated by a class of proteins called the tissue inhibitors of metalloproteinases (TIMPs). Several studies have shown that extracellular matrix degradation by MMPs, specifically MMP-9, is involved in the pathogenesis of a wide spectrum of cardiovascular disorders, including atherosclerosis, restenosis, cardiomyopathy, congestive . . . [Full Text of this Article]


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Related articles in EHJ:

Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study
Johan Sundström, Jane C. Evans, Emelia J. Benjamin, Daniel Levy, Martin G. Larson, Douglas B. Sawyer, Deborah A. Siwik, Wilson S. Colucci, Peter W.F. Wilson, and Ramachandran S. Vasan
EHJ 2004 25: 1509-1516. [Abstract] [FREE Full Text]  



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