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European Heart Journal 2004 25(17):1483-1485; doi:10.1016/j.ehj.2004.05.008
Copyright © 2004 by the European Society of Cardiology.
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Current opinion

The promise of myocardial repair – towards a better understanding

Moshe Y. Flugelman* and Basil S. Lewis1

Cardiovascular Research Center, Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center and the Bruce Rappaport School of Medicine, Technion IIT, Haifa, Israel

* Correspondence to: Moshe Y. Flugelman, Cardiovascular Research Center, Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center and the Bruce Rappaport School of Medicine, Technion IIT, Haifa, Israel. Tel.: +972-4-8250812/972-4-8250575; fax: +972-4-8250841/972-4-8250936
myf@tx.technion.ac.il

The first 150 words of the full text of this article appear below.

Despite major advances in the management of acute myocardial infarction, including effective and early urgent revascularisation, myocardial damage is common and may be severe. In many patients myocardial infarction is followed by myocardial scarring, ventricular remodelling, dilatation and reduced cardiac function followed over a period of months to years by an inexorable downhill course culminating in heart failure and death regardless of best current treatment modalities.

Myocyte regeneration – a paradigm shift

In the new millennium, we are witnessing a paradigm shift in our approach to myocardial damage, following the landmark observation that the adult heart is not necessarily a post-mitotic organ and that regeneration of cardiac myocytes may occur in the circumstances of the appropriate signalling processes.1 Within a relatively short time period, the findings from the basic science and animal laboratory have been applied in the clinical arena. Intracoronary injection of mesenchymal stromal cells (MSCs) of bone-marrow origin produced encouraging results in humans recovering . . . [Full Text of this Article]

What do we know about the mechanisms of cellular regeneration?

Temporal relations and chronic damage

Are we headed in the right direction?


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