Copyright © 2004 by the European Society of Cardiology.
ESC Expert Consensus Document
Expert Consensus Document on the Use of Antiplatelet Agents
The Task Force on the Use of Antiplatelet Agents in Patients with Atherosclerotic Cardiovascular Disease of the European Society of Cardiology
ESC Committee for Practice Guidelines (CPG),
Document Reviewers,
* Correspondence to: Carlo Patrono, Chairperson, ESC Task Force on Antiplatelets, University of Rome ‘La Sapienza’, II Facoltà di Medicina e Chirurgia, Via di Grottarossa, 1035, 00189 Roma, Italy. Tel: +39-0871-541260; fax: +39-0871-541261
| The first 150 words of the full text of this article appear below. |
1. Preamble
Guidelines and Expert Consensus Documents aim to present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic or therapeutic procedure. They should be helpful in everyday clinical decision-making.
A great number of Guidelines and Expert Consensus Documents have been issued in recent years by different organizations, the European Society of Cardiology (ESC) and by other related societies. By means of links to web sites of National Societies several hundred guidelines are available. This profusion can put at stake the authority and validity of guidelines, which can only be guaranteed if they have been developed by an unquestionable decision-making process. This is one of the reasons why the ESC and others have issued recommendations for formulating and issuing Guidelines and Expert Consensus Documents.
In spite of the fact that standards for issuing good quality Guidelines and Expert
2. Introduction
3. Platelet pathophysiology
4. Mechanism of action and clinical efficacy of antiplatelet drugs
4.1. Drugs inducing a permanent modification in platelet function
4.1.1. Aspirin
4.1.2. Ticlopidine and clopidogrel
4.2. Drugs inducing a reversible inhibition of platelet function
4.2.1. Reversible COX-1 inhibitors
4.2.2. Oral GPIIb/IIIa blockers
4.2.3. TP antagonists
4.2.4. Other P2Y12 antagonists
5. Patients that may benefit from antiplatelet therapy
6. Balance of benefits and risks of antiplatelet therapy
7. Recommendations concerning individual antiplatelet agents
7.1. Aspirin
7.2. Ticlopidine
7.3. Clopidogrel
7.4. Dipyridamole
7.5. Abciximab, eptifibatide and tirofiban
7.6. Other antiplatelet drugs
8. Areas where we need new trials
9. Conclusion
10. Summary
10.1. Antiplatelet drugs that may prevent atherothrombosis
10.2. Patients that may benefit from antiplatelet therapy
10.3. Clinical trial evidence in patients with ischaemic heart disease
10.4. Balance of benefits and risks of antiplatelet therapy
10.5. Recommendations concerning individual antiplatelet agents
10.5.1. Aspirin
10.5.2. Ticlopidine
10.5.3. Clopidogrel
10.5.4. Dipyridamole
10.5.5. Abciximab, eptifibatide and tirofiban
10.5.6. Other antiplatelet drugs
10.6. Conclusions
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