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European Heart Journal 2004 25(6):451-453; doi:10.1016/j.ehj.2004.01.019
Copyright © 2004 by the European Society of Cardiology.
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Editorial

Molecular genetics of myocardial infarction: many genes, more questions than answers

Giuseppe Vassallia,* and Bernhard R Winkelmannb,*

a Department of Cardiology, BH-10, University of Lausanne, Medical Hospital (CHUV), Rue du Bugnon 21, CH-1011 Lausanne, Switzerland
b Cooperation Unit Pharmacogenomics/Applied Genomics, University of Heidelberg, Im Neuenheimer Feld 221, D-69120 Heidelberg, Germany

* Correspondence to: Tel.: +41-213140076; fax: +41-213140013
E-mail address: giuseppe.vassalli@chuv.hospvd.ch

E-mail address: Bernhard.Winkelmann@med.uni-heidelberg.de

The first 10% of the full text of this article appears below.

This editorial refers to "Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study".1 by Martin D. Tobin et al. on page 459

In his 1999 Schattuck lecture to the Massachusetts Medical Society, Francis Collins provided an exciting vision of the development of genetically based, individualised preventive medicine by 2010.1 According to that vision, within a decade or two it should be possible to sequence anyone's entire genome for a laboratory cost of less than $1000. This would allow clinicians to provide personalised advice on environmental risk and to adapt prevention and treatment to an individual's genotype. Four years after that lecture, however, the vision of genomic medicine is not likely to materialise anytime soon.

Coronary artery disease (CAD) and myocardial infarction (MI) are complex diseases that result from a life-long interplay between genetic and environmental factors. To assess an individual's . . . [Full Text of this Article]


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Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study
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EHJ 2004 25: 459-467. [Abstract] [FREE Full Text]  



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