Copyright © 2004 by the European Society of Cardiology.
Editorial
Obstructive sleep apnoea, metabolic syndrome, and cardiovascular outcomes
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
* Corresponding author. Tel.: +1-507-284-2511/255-1144; fax: +1-507-255-7070
E-mail address: somers.virend@mayo.edu
doi: 10.1016/j.ehj.2004.02.008, 10.1016/j.ehj.2004.02.021
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This editorial refers to "Benefits of obstructive sleep aponea treatment in coronary artery disease: a long term follow-up study" by O. Milleron et al. on page 728 and "Obstructive sleep apnoea is independently associated with an increased incidence of the metabolic syndrome" SR. Coughlin et al. on page 735.3
A growing body of evidence supports an association between obstructive sleep apnoea (OSA) and cardiovascular disease. Pathophysiologic mechanisms that are present in patients with OSA – including sympathetic activation, endothelial dysfunction, oxidative stress, systemic inflammation, hypercoagulability, hyperleptinemia, and insulin resistance – may influence the development and progression of cardiac and vascular pathology.1 OSA is widely prevalent in patients with obesity, diabetes, and hypertension.1 Our understanding of the relative importance and interactions of these cardiovascular disease mechanisms and risk factors in patients with OSA may have direct implications for the development of targeted preventive and therapeutic strategies.
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Related articles in EHJ:
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EHJ 2004 25: 728-734.[Abstract] [FREE Full Text] - Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome
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