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European Heart Journal Advance Access originally published online on November 30, 2004
European Heart Journal 2005 26(1):5-7; doi:10.1093/eurheartj/ehi055
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Editorial

Obesity and heart failure prognosis: paradox or reverse epidemiology?

Carl J. Lavie*, Mandeep R. Mehra and Richard V. Milani

Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA

* Corresponding author. Tel: +1 504 842 5874; fax: +1 504 842 5875. E-mail address: clavie@ochsner.org

The first 10% of the full text of this article appears below.

Obesity is a problem reaching epidemic proportions in westernized society and is a major cause of preventable death.1 Obesity has many adverse effects on coronary artery disease (CAD) risk factors and is probably an independent risk factor for CAD events. Epidemiological studies have clearly shown a strong relationship between obesity and increased risk of cardiovascular disease and mortality in the general population,1,2 although in some of these studies a ‘J-shaped’ or ‘U-shaped’ curve has been present, meaning that those individuals with low body mass index (BMI) also have increased mortality.

Obesity is also known to exert numerous adverse effects on cardiac function. In early obesity, an expanded intravascular volume results in an increase in cardiopulmonary volume or increased pre-load.1,3 Over time these . . . [Full Text of this Article]


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