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European Heart Journal Advance Access originally published online on April 12, 2005
European Heart Journal 2005 26(12):1152-1154; doi:10.1093/eurheartj/ehi280
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Arterial stiffness: intermediate or surrogate endpoint for cardiovascular events?

Stéphane Laurent*

Department of Pharmacology and Inserm U652, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France

* Corresponding author. Tel: +33 1 56 09 39 91; fax +33 1 56 09 39 92. E-mail address: stephane.laurent@egp.ap-hop-paris.fr

This editorial refers to ‘Carotid stiffness and the risk of new vascular events in patients with manifest cardiovascular disease. The SMART study’{dagger} by J.M. Dijk et al., on page 1213

The first 10% of the full text of this article appears below.

Identification of cardiovascular (CV) risk is mandatory to determine the intensity of interventions. Despite the recognized advantages of classical algorithms for global risk assessment, important limitations have been noticed, and current research is focusing on subclinical markers of arterial disease accessible to non-invasive investigation, including arterial stiffness, carotid intima-media thickness, and endothelial dysfunction. The current growing interest in arterial stiffness originates from the repeated demonstration of its predictive value for CV events, including CV mortality, myocardial infarction, and stroke.

An indirect argument for the influence of arterial stiffness on the occurrence of CV events comes from cross-sectional studies showing that arterial stiffness and CV risk factors for atherosclerotic lesions are correlated. A major limitation of these studies is their cross-sectional feature. This is a crucial point. These studies showed that aortic stiffness was associated with other markers of CV risk or with the extent of atherosclerosis, . . . [Full Text of this Article]


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Related articles in EHJ:

Carotid stiffness and the risk of new vascular events in patients with manifest cardiovascular disease. The SMART study
Joke M. Dijk, Ale Algra, Yolanda van der Graaf, Diederick E. Grobbee, Michiel L. Bots, and on behalf of the SMART study group
EHJ 2005 26: 1213-1220. [Abstract] [FREE Full Text]