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European Heart Journal Advance Access originally published online on May 4, 2005
European Heart Journal 2005 26(14):1350-1352; doi:10.1093/eurheartj/ehi314
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Timing of arrhythmic death after myocardial infarction: does it affect timing of ICD implantation?

Federico Lombardi*

Cardiologia, Dipartimento di Medicina, Chirurgia e Odontoiatria, Osp. San Paolo, University of Milan, Via A. di Rudinì 8, 201442 Milan, Italy

* Corresponding author. Tel/fax: +39 02 50323145. E-mail address: federico.lombardi@unimi.it

This editorial refers to ‘Temporal trends on the risk of arrhythmic vs. non-arrhythmic deaths in high-risk patients after myocardial infarction: a combined analysis from multicentre trials’{dagger} by Y.G. Yap et al., on page 1385

The first 150 words of the full text of this article appear below.

In spite of significant reduction in total mortality observed in patients discharged after an acute myocardial infarction (MI), ventricular arrhythmias still account for 30–40% of deaths. This figure, which was initially provided by studies carried out in the pre-thrombolytic era, has been subsequently confirmed when most of the patients had been revascularized by thrombolysis or percutaneous coronary intervention (PCI).1

Early revascularization and a more generalized use of beta blockers, angiotensin-converting enzyme-inhibitors, statins, and antiplatelet agents have largely contributed to the improvement in the prognosis of patients presenting with an ST-elevated acute MI. Nevertheless, identification of patients at risk remains an issue far from being adequately addressed. There is a general consensus that depressed ventricular function, as reflected by a left ventricular ejection fraction (LVEF) <40%, represents the strongest negative prognostic factor in these patients.1 Different cut-off values have proved effective in recent clinical trials and an LVEF <30% has been . . . [Full Text of this Article]


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Related articles in EHJ:

Temporal trends on the risk of arrhythmic vs. non-arrhythmic deaths in high-risk patients after myocardial infarction: a combined analysis from multicentre trials
Yee Guan Yap, Trinh Duong, Martin Bland, Marek Malik, Christian Torp-Pedersen, Lars Køber, Stuart J. Connolly, Bradley Marchant, and John Camm
EHJ 2005 26: 1385-1393. [Abstract] [FREE Full Text]