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European Heart Journal Advance Access originally published online on August 10, 2005
European Heart Journal 2005 26(19):1939-1941; doi:10.1093/eurheartj/ehi449
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Exercise training: only if needed?

Joep Perk*

Kalmar County Public Health Centre, Garvaregatan 11, S-572 32 Oskarshamn, Sweden

* Corresponding author. Tel: +46 491 782000; fax: +46 491 782494. E-mail address: joep@ltkalmar.se

The first 150 words of the full text of this article appear below.

This editorial refers to ‘Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study’{dagger} by T.A. Lakka et al., on page 2018

Over the past decade, the role of inflammation in developing atherosclerotic cardiovascular disease (CVD) has been clearly demonstrated. In virtually all phases, from initiation to plaque rupture, cytokines, other bioactive molecules, and inflammatory cells are involved. The analysis of these factors could theoretically be used for diagnostic purposes. Among the cytokines and acute-phase reactants, high-sensitivity (hs) C-reactive protein has proved to be most suitable for clinical use. C-reactive protein can play an active role in the inflammatory process, which includes enhancing the uptake of damaged cells by macrophages, activating endothelial cells to express adhesion molecules, and decreasing the release of endothelial nitric oxide.

Hs-C-reactive protein has shown a dose–response relationship to ischaemic heart disease, independent of known major risk factors. Three . . . [Full Text of this Article]


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