European Heart Journal Advance Access originally published online on September 1, 2005
European Heart Journal 2005 26(20):2075-2076; doi:10.1093/eurheartj/ehi475
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Pregnancy associated plasma protein-A and coronary atherosclerosis: marker, friend, or foe?
Institute of Cardiology, Catholic University, Rome 00168, Italy
* Corresponding author. Tel: +39 06 3051166. E-mail address: filippo.crea@rm.unicatt.it
This editorial refers to Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris
by J. Cosin-Sales et al., on page 2093
| The first 10% of the full text of this article appears below. |
The natural history of coronary artery disease is complex and is characterized by the central role played by inflammation. Atherogenic stimuli, such as oxidized lipoproteins, glycation end products, hypertension, and smoking, cause endothelial dysfunction and apoptosis, vascular expression of adhesion molecules, and recruitment of inflammatory cells, which then migrate in the intima, thus setting the stage for plaque formation.1 Coronary atherosclerotic plaques have a high prevalence in the population, even in subjects dying of non-cardiac causes, and their burden increases with age.2 In many subjects these plaques remain silent for life; in others they suddenly become thrombogenic, triggering occlusive or subocclusive thrombosis, responsible for acute coronary syndromes. In survivors of a first acute coronary event, the latter is followed by a period, lasting about
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Related articles in EHJ:
- Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris
- Juan Cosin-Sales, Juan Carlos Kaski, Michael Christiansen, Paul Kaminski, Claus Oxvig, Michael T. Overgaard, Della Cole, and David W. Holt
EHJ 2005 26: 2093-2098.[Abstract] [Full Text]
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