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European Heart Journal Advance Access originally published online on September 1, 2005
European Heart Journal 2005 26(20):2079-2080; doi:10.1093/eurheartj/ehi477
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Aldosterone antagonism and atrial fibrillation: time for clinical assessment?

Stanley Nattel1,2,*

1Department of Medicine and Research Center, Montreal Heart Institute and University of Montreal, 5000 Belanger St E., Montreal, Quebec, Canada H1T 1C8
2Department of Pharmacology and Therapeutics, McGill University, Canada

* Corresponding author. Tel: +1 514 376 3330; fax: +1 514 376 1355. E-mail address: stanleynattel@aol.com

This editorial refers to ‘Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction’{dagger} by P. Milliez et al., on page 2193

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Atrial fibrillation (AF) is the most common sustained clinical arrhythmia. Presently available therapy for AF is suboptimal: ‘rhythm control’ drugs are fraught with the risk of pro-arrhythmia and other adverse effects, ‘rate control’ leaves the atria fibrillating and fails to reproduce physiological heart rate adaptation, and ablation procedures are expensive, complex, and incompletely effective. Over the past few years, the notion of ‘upstream’ therapy, targeting signalling pathways involved in the development of the substrate that supports the arrhythmia,1 has gained increased interest, supported by experimental2 and clinical3 studies which indicate that suppression . . . [Full Text of this Article]

Acknowledgement


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Related articles in EHJ:

Spironolactone reduces fibrosis of dilated atria during heart failure in rats with myocardial infarction
Paul Milliez, Noeleen DeAngelis, Catherine Rucker-Martin, Antoine Leenhardt, Eric Vicaut, Estelle Robidel, Philippe Beaufils, Claude Delcayre, and Stéphane N. Hatem
EHJ 2005 26: 2193-2199. [Abstract] [Full Text]  



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