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European Heart Journal Advance Access originally published online on October 4, 2005
European Heart Journal 2005 26(21):2213-2214; doi:10.1093/eurheartj/ehi509
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Anaemia of chronic disease in chronic heart failure: the emerging evidence

Darlington O. Okonko1,*, Dirk J. Van Veldhuisen2, Philip A. Poole-Wilson1 and Stefan D. Anker1,3

1Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
2Department of Cardiology, University Medical Centre Groningen, Groningen, The Netherlands
3Division of Applied Cachexia Research, Department of Cardiology, Charité Medical School, Campus Virchow-Klinikum, Berlin, Germany

* Corresponding author. Tel: +44 20 7351 8127; fax: +44 20 7351 8733. E-mail address: d.okonko@imperial.ac.uk

This editorial refers to ‘Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure’{dagger} by C. Opasich et al., on page 2232

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Elucidating disease pathogenesis constitutes an important aim of scientific endeavour, being critical for the identification of novel therapeutic strategies for the alleviation of suffering. Nowhere has this been more apparent than in chronic heart failure (CHF), where impressive survival benefits have been achieved as a long-term consequence of mechanistic studies into the role of neurohormonal activation in disease progression.1 Therefore, given this magnitude of potential benefit, illuminating the mechanisms that drive adverse phenomena in CHF remains an agenda of substantial importance.

Anaemia is a prevalent and adverse comorbidity in CHF, but little is known about its origins. Over the past 5 years, a plethora of studies have suggested that not only is anaemia more common in CHF than could be accounted for by age and other demographic characteristics, . . . [Full Text of this Article]

Acknowledgement


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Related articles in EHJ:

Blunted erythropoietin production and defective iron supply for erythropoiesis as major causes of anaemia in patients with chronic heart failure
Cristina Opasich, Mario Cazzola, Laura Scelsi, Stefania De Feo, Enzo Bosimini, Rocco Lagioia, Oreste Febo, Roberto Ferrari, Alessandro Fucili, Remigio Moratti, Roberto Tramarin, and Luigi Tavazzi
EHJ 2005 26: 2232-2237. [Abstract] [Full Text]  



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