European Heart Journal Advance Access originally published online on October 11, 2005
European Heart Journal 2005 26(22):2349-2350; doi:10.1093/eurheartj/ehi599
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Mirror, mirror on the wall: the quest for the earliest marker of myocardial ischaemia
Department of Cardiology, Medizinische Universitaätsklinik Heidelberg, Abteilung für Innere Medizin III, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
* Corresponding author. Tel: +49 6221 56 8670. E-mail address: hugo_katus@med.uni-heidelberg.de
This editorial refers to ‘Serum deoxyribonuclease I activity can be used as a sensitive marker for detection of transient myocardial ischaemia induced by percutaneous coronary intervention'
by K. Arakawa et al., on page 2375
| The first 10% of the full text of this article appears below. |
In patients with acute ST-segment elevation myocardial infarction (STEMI), the diagnosis and immediate initiation of reperfusion therapy is based on the standard 12-lead ECG. Owing to the fact that cardiac markers appear in the blood a substantial time after the onset of symptoms, cardiac markers are neither helpful for early diagnosis of patients with STEMI nor should results be awaited before initiation of recanalization therapy.
Unfortunately, at least 40% of all patients with confirmed acute myocardial infarction (AMI) show no diagnostic ECG changes on admission.1 In these patients with suspected acute coronary syndrome (ACS), cardiac troponins have become the biochemical gold standard for classification, risk stratification, and guidance
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- Serum deoxyribonuclease I activity can be used as a sensitive marker for detection of transient myocardial ischaemia induced by percutaneous coronary intervention
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EHJ 2005 26: 2375-2380.[Abstract] [Full Text]
This article has been cited by other articles:
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  N. Morikawa, Y. Kawai, K. Arakawa, T. Kumamoto, I. Miyamori, H. Akao, M. Kitayama, K. Kajinami, J.-D. Lee, H. Takeshita, et al. Serum deoxyribonuclease I activity can be used as a novel marker of transient myocardial ischaemia: results in vasospastic angina pectoris induced by provocation test Eur. Heart J., December 2, 2007; 28(24): 2992 - 2997. [Abstract] [Full Text] [PDF]
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E. Giannitsis and H. A. Katus Ability of DNase I activity to detect myocardial ischaemia in vasospastic angina a view through a monocle? Eur. Heart J., December 2, 2007; 28(24): 2955 - 2956. [Full Text] [PDF]
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M. K. Sinha, D. Roy, and J. C. Kaski Markers of myocardial ischaemia Eur. Heart J., March 2, 2006; 27(6): 758 - 758. [Full Text] [PDF]
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E. Giannitsis and H. A. Katus Markers of myocardial ischaemia: reply Eur. Heart J., March 2, 2006; 27(6): 759 - 759. [Full Text] [PDF]
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