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European Heart Journal Advance Access originally published online on October 11, 2005
European Heart Journal 2005 26(23):2487-2489; doi:10.1093/eurheartj/ehi578
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

First comes diagnosis then comes treatment: an underappreciated paradigm in atrial fibrillation management

Andreas Bollmann*

Department of Cardiology, University Hospital, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany

* Corresponding author. Tel: +49 391 67 13203; fax: +49 391 67 13202. E-mail address: andreas.bollmann@medizin.uni-magdeburg.de

This editorial refers to ‘Left atrial volume predicts cardiovascular events in patients originally diagnosed with lone atrial fibrillation: three-decade follow-up’{dagger} by M. Osranek et al., on page 2556

The first 10% of the full text of this article appears below.

Atrial fibrillation (AF), the most common arrhythmia encountered in clinical practice, has a very complex, incompletely understood pathophysiology with various triggers and substrates interacting in multiple ways. All, genetic pre-disposition, structural changes and fibrosis, progression of heart disease, inflammation, autonomic dysfunction coupled with electrophysiological abnormalities of the atria, and pulmonary vein sleeves, may act, to various degrees, as contributors to initiation and maintenance of the fibrillatory process. Clinically, the atrial remodelling process is accompanied by progression from paroxysmal to persistent AF, failure to restore and maintain sinus rhythm, and also increased risk of thrombogenesis and embolism.1

If one takes a closer look at current ACC/AHA/ESC AF management guidelines,1 one must realize, however, that the focus of clinical evaluation includes characterizing the pattern of the arrhythmia as paroxysmal or persistent, determining its cause, . . . [Full Text of this Article]

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Related articles in EHJ:

Left atrial volume predicts cardiovascular events in patients originally diagnosed with lone atrial fibrillation: three-decade follow-up
Martin Osranek, Francesca Bursi, Kent R. Bailey, Brandon R. Grossardt, Robert D. Brown, Jr, Stephen L. Kopecky, Teresa S. Tsang, and James B. Seward
EHJ 2005 26: 2556-2561. [Abstract] [FREE Full Text]  



This article has been cited by other articles:


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