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European Heart Journal Advance Access originally published online on October 24, 2005
European Heart Journal 2005 26(24):2603-2604; doi:10.1093/eurheartj/ehi614
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Coronary artery disease, heart failure, and cardiac natriuretic peptides in the middle

Jens Peter Goetze*

Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark

* Corresponding author. Tel: +45 3545 5509; fax: +45 3545 4640. E-mail address: jpg@dadlnet.dk

This editorial refers to ‘Plasma N-terminal pro-brain natriuretic peptide concentration predicts coronary events in men at work: a report from the BELSTRESS study’{dagger} by J. De Sutter et al., on page 2644

The first 10% of the full text of this article appears below.

An experienced cardiologist recently reminded me that most heart failure patients have a medical history of arteriosclerosis and coronary artery disease (CAD) (Figure 1). With or without myocardial infarction, the ventricular myocardium becomes hypoxic during increased workload, which, in turn, strangulates cardiac performance and initiates pathological remodelling of the myocardium. In the course of reduced left ventricular systolic function, the endocrine heart compensates with increased production and secretion of natriuretic hormones, that is, the cardiac natriuretic peptides. In fact, the association between cardiac disease and increased concentrations of natriuretic peptides was reported more than 20 years ago.1 Since then, numerous clinical studies have established that the plasma concentrations of atrial natriuretic peptide (ANP) . . . [Full Text of this Article]


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Related articles in EHJ:

Plasma N-terminal pro-brain natriuretic peptide concentration predicts coronary events in men at work: a report from the BELSTRESS study
Johan De Sutter, Dirk De Bacquer, Sofie Cuypers, Joris Delanghe, Mark De Buyzere, Marcel Kornitzer, and Guy De Backer
EHJ 2005 26: 2644-2649. [Abstract] [FREE Full Text]