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European Heart Journal Advance Access originally published online on January 11, 2005
European Heart Journal 2005 26(3):203-206; doi:10.1093/eurheartj/ehi118
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European Heart Journal vol. 26 no. 3 © The European Society of Cardiology 2005; all rights reserved.

Making sense of SENIORS

John McMurray*

Department of Cardiology, Western Infirmary, Glasgow G11 6NT, UK

* Tel: +44 141 211 1838; fax: +44 141 211 2252. E-mail address: j.mcmurray@bio.gla.ac.uk

This editorial refers to ‘Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)’{dagger} by M.D. Flather et al., on page 215

The first 10% of the full text of this article appears below.

Recently, three landmark, prospective, randomized, placebo-controlled trials demonstrated, unequivocally, that a relatively short period of treatment with certain beta-blockers (bisoprolol, target dose 10 mg once daily; carvedilol, target dose 25 mg twice daily; and metroprolol CR/XL, target dose 200 mg once daily) led to a comparable reduction in the risk of death (relative risk reduction ~33%) in patients with chronic heart failure (CHF) and a reduced left ventricular ejection fraction (LVEF).1–3 The decrease in mortality in these trials due, mainly, to a pronounced reduction in death from cardiovascular causes, was seen irrespective of symptom severity and was accompanied by similarly large . . . [Full Text of this Article]


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Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)
Marcus D. Flather, Marcelo C. Shibata, Andrew J.S. Coats, Dirk J. Van Veldhuisen, Aleksandr Parkhomenko, Joszef Borbola, Alain Cohen-Solal, Dan Dumitrascu, Roberto Ferrari, Philippe Lechat, Jordi Soler-Soler, Luigi Tavazzi, Lenka Spinarova, Jiri Toman, Michael Böhm, Stefan D. Anker, Simon G. Thompson, Philip A. Poole-Wilson, and on behalf of the SENIORS Investigators
EHJ 2005 26: 215-225. [Abstract] [Full Text]  



This article has been cited by other articles:


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D. G. Le Couteur, L. Bailey, and V. Naganathan
Beta-blockers and heart failure in older people
Eur. Heart J., April 1, 2006; 27(7): 887 - 888.
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P. C. Burger and H. B.-L. Rocca
Pharmacotherapy of Congestive Heart Failure in Elderly Patients
Journal of Cardiovascular Pharmacology and Therapeutics, April 1, 2005; 10(2): 85 - 94.
[Abstract] [PDF]