European Heart Journal Advance Access originally published online on March 8, 2005
European Heart Journal 2005 26(7):631-633; doi:10.1093/eurheartj/ehi045
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org
Recurrent pericarditis: mysterious or not so mysterious?
Department of Internal Medicine and Cardiology, Philipps University, D-35043 Marburg, Germany
* Tel: +49 6421 2866462; fax: +49 6421 2868954. E-mail address: maisch@mailer.uni-marburg.de; BerMaisch@aol.com
This editorial refers to ‘Pretreatment with corticosteroids attenuates the efficacy of colchicine in preventing recurrent pericarditis: a multi-centre all-case analysis’
by G. Artom et al., on page 723
| The first 10% of the full text of this article appears below. |
Recurrent pericarditis encompasses two forms: (i) the intermittent type with widely varying symptom-free intervals without therapy; and (ii) the incessant type, in which the discontinuation of anti-inflammatory therapy ensures a relapse. Clinical symptoms are characteristic for pericardial disease but are non-specific; they include pre-cordial pain, often associated with a pleuritic component. Fever, pericardial friction rub, dyspnoea, elevated C-reactive protein or sedimentation rate, and electrocardiogram changes are common. Massive pericardial effusion or cardiac tamponade or constriction are rare events.1 Several mechanisms have been suggested to explain recurrence: (i) insufficient dose and/or insufficient treatment duration of anti-phlogistics or corticosteroids in autoimmune or ‘idiopathic’ pericardial disease; (ii) early corticosteroid treatment causing augmented viral DNA/RNA replication in the pericardial tissue leading to increased viral antigen exposure;
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Related articles in EHJ:
- Pretreatment with corticosteroids attenuates the efficacy of colchicine in preventing recurrent pericarditis: a multi-centre all-case analysis
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EHJ 2005 26: 723-727.[Abstract] [FREE Full Text]
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