European Heart Journal Advance Access originally published online on May 9, 2006
European Heart Journal 2006 27(11):1261-1263; doi:10.1093/eurheartj/ehi852
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Linking observational and genetic approaches to determine the role of C-reactive protein in heart disease risk
1 Department of Medicine, Centre for Clinical Pharmacology, BHF Laboratories, University College London, Rayne Building, 5 University Street, London WC1E 6JJ, UK
2 Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
* Corresponding author. E-mail address: a.hingorani@ucl.ac.uk
This editorial refers to ‘C-reactive protein gene haplotypes and risk of coronary heart disease. The Rotterdam Study’
by I. Kardys et al., on page 1331
| The first 150 words of the full text of this article appear below. |
In the last decade, there has been a burgeoning interest in associations between concentrations of various circulating biomarkers and later coronary disease.1 Of these, the acute phase reactant, C-reactive protein, has garnered the greatest attention. This spotlight on C-reactive protein reflects the strength and consistency of the observed associations, the fact that C-reactive protein is a stable and readily measured analyte, and the focus on the link between inflammation and atherosclerosis. The findings led initially to the proposal that its measurement might provide useful predictive information on coronary disease risk.2 Later, the proposal was made that C-reactive protein might even play a contributory role in atherogenesis.2 Associations identified between C-reactive protein and incident blood pressure, diabetes, and metabolic syndrome were used in support of this, and experimental data from studies of vascular cells and tissues in vitro and from infusions of C-reactive protein provided preliminary evidence for pro-inflammatory, pro-adhesive, and
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Related articles in EHJ:
- C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study
- Isabella Kardys, Moniek P.M. de Maat, André G. Uitterlinden, Albert Hofman, and Jacqueline C.M. Witteman
EHJ 2006 27: 1331-1337.[Abstract] [FREE Full Text]
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