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European Heart Journal Advance Access originally published online on May 3, 2006
European Heart Journal 2006 27(11):1266-1267; doi:10.1093/eurheartj/ehl011
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Prognosis of coronary flow reserve: a new therapeutic target?

Jose Zamorano* and Borja Ruiz Mateos

Cardiovascular Imaging Unit, ICV University Clinic San Carlos, Madrid 28040, Spain

* Corresponding author. Tel: +34 91 3303290; Fax: +34 91 3303292. E-mail address: jlzamorano@vodafone.es

This editorial refers to ‘The prognostic impact of coronary flow-reserve assessed by Doppler echocardiography in non-ischaemic dilated cardiomyopathy’{dagger} by F. Rigo et al., on page 1319

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Coronary circulation, as in other vascular territories, is able to maintain its constant flow even with changes in the myocardial perfusion pressure. This physiological adaptation mechanism is defined as autoregulation. The concept of coronary flow reserve (CFR) is related to the ratio between the coronary blood flow after maximum vasodilatation, and the coronary blood flow at rest.1

The highest CFR is in the subepicardial layer of the myocardium. The CFR is lower in the subendocardial layer, so in relation to a decrease in myocardial flow, the subendocardial CFR is exhausted first. It is well known that in the absence of macroscopic coronary . . . [Full Text of this Article]


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Related articles in EHJ:

The prognostic impact of coronary flow-reserve assessed by Doppler echocardiography in non-ischaemic dilated cardiomyopathy
Fausto Rigo, Sonia Gherardi, Maurizio Galderisi, Lorenza Pratali, Lauro Cortigiani, Rosa Sicari, and Eugenio Picano
EHJ 2006 27: 1319-1323. [Abstract] [FREE Full Text]  



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F. Rigo and R. Sicari
Dilated cardiomyopathy and coronary flow reserve: reply
Eur. Heart J., August 1, 2006; 27(15): 1884 - 1885.
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