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European Heart Journal Advance Access originally published online on May 23, 2006
European Heart Journal 2006 27(12):1387-1389; doi:10.1093/eurheartj/ehi758
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Women, ‘non-specific’ chest pain, and normal or near-normal coronary angiograms are not synonymous with favourable outcome

Raffaele Bugiardini*

Dipartimento di Medicina Interna, Cardioangiologia, Epatologia (Padiglione 11), University Alma Mater of Bologna, Via Massarenti 9, 40138 Bologna, Italy

* Corresponding author. Tel: +39 051347290; Fax: +39 051347290. E-mail address: raffaele.bugiardini@unibo.it

This editorial refers to ‘Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study’{dagger} by B.D. Johnson et al., on page 1408

The first 10% of the full text of this article appears below.

One of the more troubling findings from gender-based studies is the observation that only half of women who have chest pain suggesting ischaemia present stenotic coronary lesions (>50% lumen diameter narrowing), whereas the remainder show non-obstructive or apparently normal arteries at angiography.1 Women with chest pain and non-obstructive coronary artery disease (CAD) constitute a great source of consternation to practicing physicians. Among these patients, there are an unknown number who can be shown to be suffering from cardiac pain presumed to be ischaemic. Most of these women complain of chest pain and disability for years, and the morbidity is considerable.1 New findings demonstrate that some of these patients may be at an increased risk of myocardial infarction and cardiac death.1 Advanced coronary atheroma can be present despite a normal or near-normal coronary lumen,2 and may provide a link between seemingly normal . . . [Full Text of this Article]

The prognostic value of symptoms

The quality of symptoms

Symptoms and clinical presentations

Take care of women

From the male to the female standard

Conclusions


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Related articles in EHJ:

Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study
B. Delia Johnson, Leslee J. Shaw, Carl J. Pepine, Steven E. Reis, Sheryl F. Kelsey, George Sopko, William J. Rogers, Sunil Mankad, Barry L. Sharaf, Vera Bittner, and C. Noel Bairey Merz
EHJ 2006 27: 1408-1415. [Abstract] [FREE Full Text]  



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[Full Text] [PDF]