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European Heart Journal Advance Access originally published online on May 23, 2006
European Heart Journal 2006 27(12):1392-1393; doi:10.1093/eurheartj/ehl048
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Regression of left ventricular mass and wall thickness after cardiac resynchronization therapy: proof of pathophysiological concept

Herman Mannaerts*

Department of Cardiology, Amstelland Hospital, Amstelveen, and VU University Medical Center, Amsterdam, The Netherlands

* Corresponding author. Tel: +31 204442244; fax: +31 204442446. E-mail address: hermanmannaerts@wanadoo.nl

This editorial refers to ‘Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure’{dagger} by Q. Zhang et al., on page 1423

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Cardiac resynchronization therapy (CRT) has become an established therapy for patients with NYHA class 3 and 4 heart failure, with a left ventricular (LV) ejection fraction (EF) <35%, and a wide QRS complex of >120 ms, especially in patients with a complete left bundle branch block (CLBBB).1 A number of studies have shown that patients with these characteristics may benefit from this therapy in terms of quality-of-life (QoL), exercise capacity, LV function, LV dimensions/volumes, morbidity, and even mortality.1 The key to understanding these effects lies in the term asynchrony as the most important determinant for success of CRT. Asynchrony, which means that parts of the heart and particularly the LV are out of phase during LV contraction and relaxation, can occur at three levels within the . . . [Full Text of this Article]


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Related articles in EHJ:

Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure
Qing Zhang, Jeffrey Wing-Hong Fung, Angelo Auricchio, Joseph Yat-Sun Chan, Leo C.C. Kum, Li Wen Wu, and Cheuk-Man Yu
EHJ 2006 27: 1423-1430. [Abstract] [FREE Full Text]  



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