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European Heart Journal Advance Access originally published online on June 7, 2006
European Heart Journal 2006 27(13):1519-1520; doi:10.1093/eurheartj/ehl065
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Oestrogen receptor genetics: a needle that cuts through many haystacks?

Amanda M. Shearman*

Center for Cancer Research, Massachusetts Institute of Technology, E17-536, Cambridge, MA 02139, USA

* Corresponding author. fax: +1 617 253 5202. E-mail address: shearman@mit.edu

This editorial refers to ‘The association of oestrogen receptor {alpha}-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study’{dagger} by D.A. Lawlor et al., on page 1597

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Oestrogen is known to affect multiple aspects of human health, including complex traits such as cardiovascular disease, cancer, fracture risk, arthritis, behaviour and Alzheimer's disease. Oestrogen receptor {alpha} (ESR1), one of two known oestrogen activated transcription factors, is expressed throughout many tissues. It can regulate gene expression by both oestrogen-dependent and oestrogen-independent mechanisms that result in direct or indirect activation of transcription of a wide range of genes. Most of the hundreds of reports of ESR1 genetics published since 1990 have been in areas of cancer biology, bone mineral density, or fracture risk. In the past 3 or 4 years, however, there have been a handful of interesting reports . . . [Full Text of this Article]


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Related articles in EHJ:

The association of oestrogen receptor {alpha}-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study
Debbie A. Lawlor, Nick Timpson, Shah Ebrahim, Ian N.M. Day, and George Davey Smith
EHJ 2006 27: 1597-1604. [Abstract] [FREE Full Text]  



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Pharmacol. Rev., June 1, 2008; 60(2): 210 - 241.
[Abstract] [Full Text] [PDF]