European Heart Journal Advance Access originally published online on June 16, 2006
European Heart Journal 2006 27(14):1635-1636; doi:10.1093/eurheartj/ehl090
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
NSAIDS and the risk of myocardial infarction: do they help or harm?
Cleveland Clinic Cardiovascular Coordinating Center, Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA
* Corresponding author. Tel: +1 216 445 4042; fax: +1 216 445 8531. E-mail address: bhattd@ccf.org
This editorial refers to ‘NSAID use and the risk of hospitalization for first myocardial infarction in the general population: a nationwide case–control study from Finland’
by A. Helin-Salmivaara et al., on page 1657
| The first 10% of the full text of this article appears below. |
Non-steroidal anti-inflammatory drugs (NSAIDS) are commonly used for pain relief and appear to work primarily by inhibiting cyclooxygenase (COX) enzymes. Aspirin and other traditional NSAIDS non-selectively inhibit both COX-1 and COX-2 isoforms. In contradistinction, the various coxibs more selectively inhibit COX-2, with differing degrees of specificity. Aspirin has unequivocally been demonstrated to reduce myocardial infarction (MI) in patients with established coronary artery disease.1 The predominant mechanism by which aspirin provides cardiovascular protection is believed to be via irreversible inhibition of COX-1-mediated platelet aggregation. Prior reports in the literature regarding cardiovascular effects of NSAIDS have been conflicting, whereas the cardiovascular effect of COX-2 inhibitors has been nothing but controversial.
The important report by Helin-Salmivaara et al. in this issue of the European Heart Journal is the largest population-based matched case–control study of NSAIDS performed to date.2 A total
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Related articles in EHJ:
- NSAID use and the risk of hospitalization for first myocardial infarction in the general population: a nationwide case–control study from Finland
- Arja Helin-Salmivaara, Arja Virtanen, Risto Vesalainen, Juha M. Grönroos, Timo Klaukka, Juhana E. Idänpään-Heikkilä, and Risto Huupponen
EHJ 2006 27: 1657-1663.[Abstract] [FREE Full Text]
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