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European Heart Journal Advance Access originally published online on June 21, 2006
European Heart Journal 2006 27(14):1637-1639; doi:10.1093/eurheartj/ehl118
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Pregnancy-associated plasma protein-A and cardiovascular risk

Juan Carlos Kaski* and David W. Holt

Division of Cardiac and Vascular Sciences, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK

* Corresponding author. Tel: +44 20 8725 5901; fax: +44 20 8725 3328. E-mail address: jkaski@sgul.ac.uk

This editorial refers to ‘Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina’{dagger} by A.A. Elesber et al., on page 1678

The first 150 words of the full text of this article appear below.

Coronary artery disease (CAD) progression leading to acute coronary syndrome (ACS) is a rather unpredictable phenomenon. Clinicians currently depend on relatively crude risk scores to identify individuals at risk of developing serious cardiovascular events. Conventional risk factors are able to single out only a proportion of those individuals at a high risk of developing fatal cardiac events. The fact that both atherogenesis and atherosclerotic cardiovascular disease progression are directly linked to inflammatory mechanisms has generated interest among scientists as to the potential role of inflammatory molecules as markers of cardiovascular risk. C-reactive protein, a marker of inflammation, has been shown to add value to the predictive ability of conventional risk factors. However, given the complexity of the mechanisms responsible for both disease progression and acute events, it is unlikely that a single molecule can provide clinicians with an accurate prediction of cardiovascular risk. Current markers, including C-reactive protein, are non-specific . . . [Full Text of this Article]

PAPP-A: pathogenic mechanism or marker of atherosclerosis?

Problems with current PAPP-A assays

Future directions


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Related articles in EHJ:

Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina
Ahmad A. Elesber, Cheryl A. Conover, Ali E. Denktas, Ryan J. Lennon, David R. Holmes, Jr, Michael T. Overgaard, Michael Christiansen, Claus Oxvig, Lilach O. Lerman, and Amir Lerman
EHJ 2006 27: 1678-1684. [Abstract] [Full Text]