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European Heart Journal Advance Access originally published online on July 4, 2006
European Heart Journal 2006 27(16):1893-1894; doi:10.1093/eurheartj/ehl140
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Anticoagulation for stroke prevention in atrial fibrillation: is gender important?

Gregory Y.H. Lip*, Timothy Watson and Eduard Shantsila

Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham B18 7QH, England, UK

* Corresponding author. Tel: +44 121 507 5080; fax: +44 121 554 4803. E-mail address: g.y.h.lip@bham.ac.uk

This editorial refers to ‘Anticoagulation in women with non-valvular atrial fibrillation in the stroke prevention using an oral thrombin inhibitor (SPORTIF) trials’{dagger} by M. Gomberg-Maitland et al., on page 1947

The first 10% of the full text of this article appears below.

The presence of atrial fibrillation (AF) confers a five-fold increased risk of stroke, a figure that may rise to as high as 17 times in the presence of structural heart disease, in particular mitral stenosis. It is estimated that 15% of all strokes may be directly attributable to AF, but of greater concern is that when patients with AF have a stroke, they have a much worse outcome. Being an increasingly more prevalent arrhythmia and given the increasing mean age of the general population, AF presents a significant economic burden.

Why does AF confer such a high risk of stroke and thrombo-embolism? The loss of co-ordinated atrial contraction in AF, associated with stasis and structural (and electrical) remodelling . . . [Full Text of this Article]


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Related articles in EHJ:

Anticoagulation in women with non-valvular atrial fibrillation in the stroke prevention using an oral thrombin inhibitor (SPORTIF) trials
Mardi Gomberg-Maitland, Nanette K. Wenger, Jan Feyzi, Maria Lengyel, Annabelle S. Volgman, Palle Petersen, Lars Frison, and Jonathan L. Halperin
EHJ 2006 27: 1947-1953. [Abstract] [Full Text]  



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